Institute of Biomedical & Clinical Science: Recent submissions
Now showing items 16-20 of 1236
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The role of sodium-glucose co-transporter-2 inhibitors in frail older adults with or without type 2 diabetes mellitus
(Oxford University Press / British Geriatrics Society, 6 October 2022)Sodium-glucose co-transporter-2 (SGLT2) inhibitors offer significant outcome benefits beyond glucose lowering including reduced risk of cardiovascular death, all-cause mortality, major adverse cardiovascular events, ... -
Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions
(IOS Press, 16 August 2022)Psychotic phenomena are among the most severe and disruptive symptoms of dementias and appear in 30% to 50% of patients. They are associated with a worse evolution and great suffering to patients and caregivers. Their ... -
Detection and characterization of male sex chromosome abnormalities in the UK Biobank study
(Elsevier / American College of Medical Genetics and Genomics, 9 June 2022)PURPOSE: The study aimed to systematically ascertain male sex chromosome abnormalities, 47,XXY (Klinefelter syndrome [KS]) and 47,XYY, and characterize their risks of adverse health outcomes. METHODS: We analyzed genotyping ... -
Objective assessment of sleep regularity in 60 000 UK Biobank participants using an open-source package
(Oxford University Press (OUP) / Sleep Research Society, 8 November 2021) -
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study
(American Diabetes Association, 29 March 2022)OBJECTIVE: To examine the effects of sleep traits on glycated hemoglobin (HbA1c). RESEARCH DESIGN AND METHODS: This study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian ...