Show simple item record

Seven newly identified loci for autoimmune thyroid disease

dc.contributor.authorCooper, JD
dc.contributor.authorSimmonds, MJ
dc.contributor.authorWalker, NM
dc.contributor.authorBurren, O
dc.contributor.authorBrand, OJ
dc.contributor.authorGuo, H
dc.contributor.authorWallace, C
dc.contributor.authorStevens, H
dc.contributor.authorColeman, G
dc.contributor.authorWellcome Trust Case Control Consortium
dc.contributor.authorFranklyn, JA
dc.contributor.authorTodd, JA
dc.contributor.authorGough, SCL
dc.date.accessioned2017-07-24T14:18:39Z
dc.date.issued2012-12-01
dc.description.abstractAutoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.en_GB
dc.description.sponsorshipThe research leading to these results has received funding from the European Union’s 7th Framework Programme (FP7/2007– 2013) under grant agreement No. 241447 [Natural immunomodulators as novel immunotherapies for type 1 diabetes (NAIMIT)]. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.en_GB
dc.identifier.citationVol. 21, pp. 5202 - 5208en_GB
dc.identifier.doi10.1093/hmg/dds357
dc.identifier.otherdds357
dc.identifier.urihttp://hdl.handle.net/10871/28600
dc.language.isoenen_GB
dc.publisherOxford University Press (OUP)en_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/22922229en_GB
dc.rights© The Author 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectAutoimmune Diseasesen_GB
dc.subjectCase-Control Studiesen_GB
dc.subjectChromosome Bandingen_GB
dc.subjectChromosome Mappingen_GB
dc.subjectFemaleen_GB
dc.subjectGenetic Locien_GB
dc.subjectGenetic Predisposition to Diseaseen_GB
dc.subjectGraves Diseaseen_GB
dc.subjectHashimoto Diseaseen_GB
dc.subjectHumansen_GB
dc.subjectMaleen_GB
dc.subjectPolymorphism, Single Nucleotideen_GB
dc.subjectThyroid Diseasesen_GB
dc.titleSeven newly identified loci for autoimmune thyroid diseaseen_GB
dc.typeArticleen_GB
dc.date.available2017-07-24T14:18:39Z
dc.identifier.issn0964-6906
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is the final version of the article. Available from the publisher via the DOI in this record.en_GB
dc.identifier.journalHuman Molecular Geneticsen_GB
dc.identifier.pmcidPMC3490518
dc.identifier.pmid22922229


Files in this item

Name:
Seven newly identified loci for ...
Size:
111.5Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record