Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an EWAS meta-analysis

Schellhas, L; Monasso, GS; Felix, JF; et al.Jaddoe, VWV; Huang, P; Fernández-Barrés, S; Vrijheid, M; Pesce, G; Annesi-Maesano, I; Page, CM; Brantsæter, A-L; Bekkhus, M; Håberg, SE; London, S; Munafò, MR; Zuccolo, L; Sharp, GC
Date: 2023
Journal
Epigenomics
Publisher
Future Medicine
Abstract
Background: Prenatal caffeine exposure may influence offspring health via DNA methylation (DNAm) but no large studies have tested this. Materials & Methods: Epigenome-wide association studies and differentially methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts ...
Background: Prenatal caffeine exposure may influence offspring health via DNA methylation (DNAm) but no large studies have tested this. Materials & Methods: Epigenome-wide association studies and differentially methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts (n = 3742), Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea, and cola was compared to assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. 12-22 DMRs were detected with limited overlap across caffeinated beverages. Conclusions: We found little evidence to support an intrauterine effect of caffeine on
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Psychology

Faculty of Health and Life Sciences

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