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Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an EWAS meta-analysis

dc.contributor.authorSchellhas, L
dc.contributor.authorMonasso, GS
dc.contributor.authorFelix, JF
dc.contributor.authorJaddoe, VWV
dc.contributor.authorHuang, P
dc.contributor.authorFernández-Barrés, S
dc.contributor.authorVrijheid, M
dc.contributor.authorPesce, G
dc.contributor.authorAnnesi-Maesano, I
dc.contributor.authorPage, CM
dc.contributor.authorBrantsæter, A-L
dc.contributor.authorBekkhus, M
dc.contributor.authorHåberg, SE
dc.contributor.authorLondon, S
dc.contributor.authorMunafò, MR
dc.contributor.authorZuccolo, L
dc.contributor.authorSharp, GC
dc.date.accessioned2023-11-02T15:38:22Z
dc.date.issued2023
dc.date.updated2023-11-02T11:17:47Z
dc.description.abstractBackground: Prenatal caffeine exposure may influence offspring health via DNA methylation (DNAm) but no large studies have tested this. Materials & Methods: Epigenome-wide association studies and differentially methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts (n = 3742), Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea, and cola was compared to assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. 12-22 DMRs were detected with limited overlap across caffeinated beverages. Conclusions: We found little evidence to support an intrauterine effect of caffeine onen_GB
dc.description.sponsorshipMedical Research Council (MRC)en_GB
dc.identifier.citationAwaiting citation and DOIen_GB
dc.identifier.urihttp://hdl.handle.net/10871/134402
dc.identifierORCID: 0000-0003-2906-4035 (Sharp, Gemma)
dc.identifierScopusID: 56898577600 (Sharp, Gemma)
dc.language.isoenen_GB
dc.publisherFuture Medicineen_GB
dc.rights.embargoreasonUnder temporary indefinite embargo pending publication by Future Medicine. No embargo required on publication en_GB
dc.subjectcaffeineen_GB
dc.subjectpregnancyen_GB
dc.subjectoffspring healthen_GB
dc.subjectepigeneticsen_GB
dc.subjectDNA methylationen_GB
dc.subjectPACE consortiumen_GB
dc.titleMaternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an EWAS meta-analysisen_GB
dc.typeArticleen_GB
dc.date.available2023-11-02T15:38:22Z
dc.identifier.issn1750-1911
dc.descriptionThis is the author accepted manuscript.en_GB
dc.identifier.journalEpigenomicsen_GB
dc.relation.ispartofEpigenomics
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2023-11-02
dcterms.dateSubmitted2023-07-20
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2023-11-02
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-11-02T11:17:52Z
refterms.versionFCDAM
refterms.panelAen_GB


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